Which of the following statements about the GO (G zero phase) phase of the cell cycle is most accurate?
- AOption (a)
DNA synthesis occurs rapidly in cells present in the GO phase.
- BOption (b)
It is the phase where cell division is initiated in cancerous cells.
- COption (c)
It is a temporary quiescent stage where cells exit the cell cycle.
- DOption (d)
Cells in GO actively prepare for DNA replication.
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Correct answer
It is a temporary quiescent stage where cells exit the cell cycle.
Why this answer is correct
The correct answer is It is a temporary quiescent stage where cells exit the cell cycle..
Key Points
- The GO phase (G zero phase) represents a state of cell cycle arrest, where cells exit the active cycle and stop dividing.
- Cells in the GO phase are in a non-proliferative or quiescent state, often performing specialized functions depending on the cell type.
- This phase is temporary or permanent, depending on the cell type and environmental conditions.
- Examples of cells in permanent GO phase include neurons and skeletal muscle cells, which do not divide after differentiation.
- GO phase is crucial for maintaining cellular homeostasis and protecting against uncontrolled cell division.
Additional Information
- Cell Cycle Phases:
- The cell cycle consists of interphase (G1, S, G2 phases) and mitotic phase (M phase).
- GO phase is not part of the active cycle and is considered a resting state.
- Quiescence vs Senescence:
- Quiescence refers to reversible cell cycle arrest (GO phase).
- Senescence is an irreversible state of cell cycle arrest caused by damage or aging.
- Role in Cancer:
- Cancerous cells often evade GO phase, leading to uncontrolled division and tumor formation.
- Targeting the mechanisms regulating GO phase is a focus in cancer therapy research.
- Cell Types:
- Stem cells can exit GO phase to re-enter the cycle and divide.
- Terminally differentiated cells like neurons remain in GO phase permanently.