Which of the following is an inactivated (killed) polio vaccine developed in 1952?
- AOption (a)
Salk vaccine
- BOption (b)
Imvanex vaccine
- COption (c)
HDCV vaccine
- DOption (d)
TAB vaccine
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Correct answer
Salk vaccine
Why this answer is correct
The correct answer is the Salk Vaccine
Key Points
- The inactivated poliovirus vaccine (IPV), or Salk vaccine, was developed in the 1950s by American physician Jonas Salk and first used in 1955:
- IPV is a mixture of three inactivated poliovirus strains, one from each serotype.
- The poliovirus strains are grown in Vero cells and inactivated with formaldehyde.
- IPV is given by intramuscular or subcutaneous injection.
- IPV reduced the number of paralytic polio cases from about 20,000 per year to around 2,000. It also eradicated polio in Scandinavia and the Netherlands.
- The initial formula developed by Salk was replaced by an enhanced potency formula in the late 1980s.
- In the 1960s, Dr. Albert Sabin developed a live attenuated (weakened) oral polio vaccine (OPV).
- OPV was shown to interrupt epidemics and break viral transmission, leading to the elimination of the virus from entire continents by the 1980s.
