Which class of immunoglobulin is the first to be produced in response to an infection?
- AOption (a)
IgA
- BOption (b)
IgG
- COption (c)
IgM
- DOption (d)
IgE
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Correct answer
IgM
Why this answer is correct
The Correct Answer is Option 3
Key Points What are Immunoglobulins?
- Immunoglobulins (Ig) or antibodies are proteins produced by B cells in response to antigens (foreign substances like viruses or bacteria).
- There are five major classes: IgG, IgA, IgM, IgE, and IgD, each with different roles.
Why IgM is the First?
- IgM is the first antibody produced during the primary immune response (initial exposure to an antigen).
- It is a pentamer (5 antibody units), making it highly effective at agglutination and activating complement proteins.
- It provides early defense before other antibodies like IgG are produced in larger amounts.
Why the other options are incorrect?
- 1) IgA – Found mainly in mucosal areas (e.g., saliva, tears, breast milk), not first in systemic response.
- 2) IgG – Most abundant in the blood and produced in secondary response, not the first.
- 4) IgE – Involved in allergic reactions and defense against parasites, not the initial response to infection.
Conclusion:
IgM is the first class of immunoglobulin to be produced in response to a new infection, acting as the body’s first line of antibody defense.
So, the correct answer is: Option 3.