Match the LIST-I with LIST-II
| LIST-I | LIST-II |
|---|---|
| A. Dichlorvos | I. Type A organophosphate insecticide |
| B. Melathion | II. Type B organophosphate insecticide |
| C. Parathion | III. Type C organophosphate insecticide |
| D. Lindane | IV. Organochlorine Insecticide |
- AOption (a)
A-II, B-III, C-I, D-IV
- BOption (b)
A-IV, B-II, C-III, D-I
- COption (c)
A-I, B-III, C-II, D-IV
- DOption (d)
A-I, В-II, C-III, D-IV
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Correct answer
A-I, B-III, C-II, D-IV
Why this answer is correct
The correct answer is: A‑I, B‑III, C‑II, D‑IV.
Insecticides are classified by chemical family and, for organophosphates (OPs), by subtype reflecting structural features and metabolic behavior that determine how strongly they inhibit acetylcholinesterase (AChE). Correctly mapping each compound to its class clarifies toxicity profile, environmental fate, and therapeutic management in exposures. Organochlorines constitute a distinct, persistent class with mechanisms different from OPs.
Key Points
| List‑I (Compound) | List‑II (Category) |
|---|---|
| A. Dichlorvos (DDVP) | I. Type A organophosphate insecticide |
| B. Malathion | III. Type C organophosphate insecticide |
| C. Parathion | II. Type B organophosphate insecticide |
| D. Lindane (γ‑HCH) | IV. Organochlorine insecticide |
- Dichlorvos → Type A organophosphate
- Volatile dimethyl phosphate that is inherently active; rapidly inhibits AChE without requiring extensive bioactivation.
- Fast knock‑down action in vapour and contact uses; comparatively short environmental persistence among OPs.
- Malathion → Type C organophosphate
- Thiono OP that forms the potent oxon (malaoxon) on oxidative desulfuration; mammalian detoxification by carboxylesterases makes it less acutely toxic than many OPs.
- Widely used for agricultural pests and vector control programs.
- Parathion → Type B organophosphate
- Bioactivated to paraoxon, a very strong AChE inhibitor; historically associated with severe poisonings, hence heavily restricted/banned in many regions.
- Represents a highly toxic OP subgroup with pronounced oxon‑mediated inhibition.
- Lindane → Organochlorine insecticide
- Gamma isomer of hexachlorocyclohexane; acts mainly by interfering with GABA‑gated chloride channels in the nervous system.
- Persistent and bioaccumulative; stringent global regulatory controls due to environmental and health risks.
Additional Information
- Mechanism and management of OP toxicity:
- All OPs inhibit acetylcholinesterase, causing acetylcholine accumulation and cholinergic symptoms (muscarinic, nicotinic, CNS).
- Treatment involves prompt atropine, an oxime reactivator (e.g., pralidoxime), decontamination, and respiratory support; early therapy prevents “aging” of the phosphorylated enzyme.
- Why classification matters:
- Subtype hints at need for metabolic activation, relative mammalian toxicity, and expected persistence—useful for risk assessment, PPE selection, and antidote planning.
- Environmental contrast:
- Organochlorines like lindane and DDT are persistent organic pollutants with long half‑lives and bioaccumulation, whereas OPs degrade faster but pose high acute toxicity to non‑target organisms.
- Applied takeaway:
- Accurate mapping of compound→class supports safer pesticide selection, regulatory compliance, residue monitoring, and emergency response protocols.




