Which of the following neurotoxins are used to produce selective chemical lesion in the study of brain behaviour relationship?
A. Dopaminesterage
B. Kainic acid
C. Deoxyglucose
D. Ibotenic acid
E. 6-Hydroxydopamine
Choose the correct answer from the options given below:
- AOption (a)
A, C and D Only
- BOption (b)
B, C and E Only
- COption (c)
A, B and C Only
- DOption (d)
B, D and E Only
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Correct answer
B, D and E Only
Why this answer is correct
The correct answer is 'B, D, and E.'.
Key Points
- Neurotoxins used for selective chemical lesions:
- These neurotoxins are chemical agents used to selectively destroy specific neurons in the brain. This technique helps researchers understand the role of different brain regions in behavior and physiological processes.
- Kainic acid: A neurotoxin that selectively kills neurons by activating glutamate receptors, leading to excitotoxicity. It is commonly used to study conditions like epilepsy and neurodegenerative diseases.
- Ibotenic acid: Another neurotoxin that acts on glutamate receptors, particularly NMDA and metabotropic receptors, causing neuronal death. It is used to create lesions in specific brain regions to study their functions.
- 6-Hydroxydopamine (6-OHDA): A neurotoxin that selectively destroys dopaminergic and noradrenergic neurons. It is extensively used in animal models to study Parkinson's disease and other disorders involving these neurotransmitter systems.
Additional Information
- Other Options Explanation:
- Dopaminesterage: There is no known neurotoxin by this name. It might be a misnomer or confusion with enzymes related to dopamine metabolism, like monoamine oxidase.
- Deoxyglucose: This compound is used in metabolic studies, particularly in imaging techniques like PET scans, to measure glucose utilization in the brain. It is not used to produce lesions.
- Importance of Selective Lesions:
- Selective chemical lesions are crucial for understanding the functional organization of the brain. By selectively destroying specific neurons, researchers can study the resulting behavioral and physiological changes, providing insights into the roles of different brain regions.