Held in 2012
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Choose the correct solvents for coating materials
Glycerin
Propylene glycol
Water
Acetone
Correct answer
Glycerin
Buffering agent used for parenteral preparation is
Sodium metabolite
Sorbitol
Carbolic acid
Benzyl alcohol
Correct answer
Sodium metabolite
Choose the correct excipient for enhancing the solubility in tablet manufacturing
Lactose
Talc
Microcrystalline cellulose
PEG
Correct answer
Lactose
One of the units used for expressing pressure in Torr and is equal to
Gauss
Psi
cm of Hg
mm of Hg
Correct answer
Gauss
In the process of sugar coating of tablets the colorants are added in one of the following steps
Syrup coating
Seal coating
Sub coating
Polishing
Correct answer
Syrup coating
The shell of soft gelatin capsule may be elastic or plastic-like, by the addition of
Povidone
HPMC
PEG
Sorbitol
Correct answer
Povidone
One of the materials listed below is commonly used in film coating of tablets
Acacia
HPMC
Bees wax
Simple syrup
Correct answer
Acacia
As per G.M.P. permitted limit of solid contents in water for injection is
100 ppm
1.0 ppm
0.1 ppm
10 ppm
Correct answer
100 ppm
Nujol is
Hexachlorobutadiene
Mineral oil
Perfluorokerosene
Fluorolube
Correct answer
Hexachlorobutadiene
Which of the following is a microsomal enzyme inducer?
Indomethacin
Clofibrate
Tolbutamide
Glutethamide
Correct answer
Indomethacin
Fiducial limit is a term used in
Microbiological assay
Biological assay
Chemical assay
Instrumental methods of assay
Correct answer
Microbiological assay
Phenothiazines are metabolized
In the hepatic microsomal system by hydroxylation followed by conjugation with glucuronic acid
In the liver by oxidation
In the hepatic microsomal system by reduction
In the hepatic microsomal system by oxidation followed by conjugation with glycine
Correct answer
In the hepatic microsomal system by hydroxylation followed by conjugation with glucuronic acid
Benzodiazepines potentiate
The binding of protein to nervous tissue
The binding of GABA to liver
The binding of GABA to receptors
The binding of GABA to carbohydrates
Correct answer
The binding of protein to nervous tissue
Benzalkonium chloride is a germicidal surfactant which is rendered inactive in the presence of
Organic acid
Cationic surfactants
Soaps
Inorganic salts
Correct answer
Organic acid
Which constituent of Guguliipid is responsible for hypolipidemic activity
Gums
Gugguisterones E and Z
Gugguisterol I and II
All of the above
Correct answer
Gums
Which one of the following is S-glycoside?
Digoxin
Sennoside A
Aloin
Sinigrin
Correct answer
Digoxin
Which of the following is true about microscopy of Rauwolfia tetraphylla?
Absence of sclereids
Non-stratified
Larger xylem vessels
All cells are lignified as well as suberized
Correct answer
Absence of sclereids
Ergot gives a blue color with alkali due to the presence of
Tryptophan residues
Indole ring
Ergotoxine
Lysergic Acid
Correct answer
Tryptophan residues
Ergotine nucleus is derived from
Ornithine and phenylalanine
Tryptophan and phenylalanine
Tryptophan and mevalonate
5-Hydroxy tryptamine and phenylalanine
Correct answer
Ornithine and phenylalanine
Eserine alkaloids consist of which heterocyclic rings fused together?
Indole and pyrrole
Indolidine and pyridine
Indoline and pyrrolidine
Indolidine and piperidine
Correct answer
Indole and pyrrole
True statement regarding nitric oxide is
NO synthesized from arginine
NO produced spontaneously from NO2
NO causes vasoconstriction
NO released from mitochondria
Correct answer
NO synthesized from arginine
Glucose can be synthesized from all of the following except
Acetoacetate
Lactic acid
Glycerol
Amino acid
Correct answer
Acetoacetate
Gout is a disorder of
Protein metabolism
Pyrimidine metabolism
Oxalate metabolism
Purine metabolism
Correct answer
Protein metabolism
Most common cause of aortic aneurysm is
Syphilis
Marfan’s
Atherosclerosis
Congenital
Correct answer
Syphilis
Hemorrhagic infarct may be seen in
Brain
Spleen
Lung
Heart
Correct answer
Brain
The commonest histological types of lung carcinoma in India are
Squamous cell carcinoma
Adenocarcinoma
Small cell carcinoma
Large cell carcinoma
Correct answer
Squamous cell carcinoma
The pathological appearance in pseudomembrane colitis is
Necrosis and gangrene
Small ulceration with slough
Serositis covered by membrane
Excessive ulceration in serosa
Correct answer
Necrosis and gangrene
All of the following arteries supply to the stomach except
Rt. Gastric artery
Lt. Gastric artery
Splenic artery
Inferior mesenteric artery
Correct answer
Rt. Gastric artery
Which organ has dual blood supply?
Liver
Pancreas
Testis
Duodenum
Correct answer
Liver
Which of the following spaces will the infection of the index finger spread?
Mid-palmar space
Radial bursa
Thenar space
Dorsum of hand
Correct answer
Mid-palmar space
The increased incidence of infection in the ischio-rectal fossa is due to
Absence of deep fascia
Proximity to anus
Poor blood supply
Presence of fibrofatty tissue
Correct answer
Absence of deep fascia
All are true regarding capillaries except
Have large total cross-sectional area
Contain larger quantity of blood than veins
Site of gaseous exchange
Lined by endothelium
Correct answer
Have large total cross-sectional area
Hyaline membrane contains
Albumin
WBCs
Globulin
Fibrin
Correct answer
Albumin
Which is the best parameter for analysis of hypoxic hypoxia?
Arterial PO2
Arterial PCO2
Venous PO2
A-V difference
Correct answer
Arterial PO2
Malaria is caused by
Plasmodium falciparum
Plasmodium vivax
Plasmodium malariae
All of the above
Correct answer
Plasmodium falciparum
Which of the following are not surface infections?
Rabies
Syphilis
Tetanus
Trachoma
Correct answer
Rabies
All of the following can cause urinary tract infections except
Proteus
Staphylococci
Faecal streptococci
E. coli
Correct answer
Proteus
Principal structural component of the cell wall in bacteria is made up of
Complex polysaccharides
Simple protein
Glycoprotein
Peptidoglycan
Correct answer
Complex polysaccharides
Which of the following are simple RNA viruses except
Rotavirus
Influenza virus
Rabies virus
Poliovirus
Correct answer
Rotavirus
Adjuvant is a substance which
Enhances antibody actions
Enhances adherence of antibody
Enhances immunogenicity
Enhances antibody efficacy
Correct answer
Enhances antibody actions
Which of the following is used as preservative in ophthalmic preparation?
Chlorocresol
Phenol
Benzoic acid
Benzalkonium chloride
Correct answer
Chlorocresol
Which of the following is used as a local anesthetic in the formulation of parenteral products?
Acetic acid
Ethyl alcohol
Benzyl alcohol
Sorbitol
Correct answer
Acetic acid
Commonly used antioxidant for the oil system is
Thioglycol
Ascorbic acid
Sodium metabisulphite
Butylated hydroxytoluene
Correct answer
Thioglycol
Half-life equation for first-order reaction is
\([ T_{1/2} = \frac{a}{2k} ]\)
\([ T_{1/2} = \frac{0.693}{k} ]\)
\([ T_{1/2} = \frac{1}{2a^2k} ]\)
\([ T_{1/2} = \frac{1}{ak} ]\)
Correct answer
\([ T_{1/2} = \frac{a}{2k} ]\)
Isotonic solution is
0.1 % NaCl
0.5 % NaCl
1.6 % NaCl
0.9 % NaCl
Correct answer
0.1 % NaCl
In cosmetic preparation, antioxidants used in an aqueous system
Sodium formaldehyde
Phenol
Alpha tocopherol
Methyl paraben
Correct answer
Sodium formaldehyde
A typical auxin of plants is
2, 4-D
NAA
Indole-3-acetic acid
Gibberellic acid
Correct answer
2, 4-D
Anthracene has carcinogenic activity
In general
If heated in air
If metabolized
In ultraviolet light
Correct answer
In general
Best method to estimate blood cholesterol level
Colorimetric method
Schales’ method
Fehling’s method
Bricker and Butler method
Correct answer
Colorimetric method
Amino acid which is a precursor of serotonin
Tyrosine
Tryptophan
Lysine
Methionine
Correct answer
Tyrosine
In non-titration of amine halides, the halide ion is removed by the addition of
Ethyl acetate
Sodium acetate
Cellulose acetate
Mercuric acetate
Correct answer
Ethyl acetate
Milk of magnesia is a preparation containing between 7 and 8.5% of
Magnesium hydroxide
Magnesium gluconate
Magnesium perchlorate
Magnesium oxide
Correct answer
Magnesium hydroxide
Light-liquid paraffin IP and Liquid Paraffin IP are differentiated by their
Flash point
Appearance
Pour point
Odour
Correct answer
Flash point
Chronic administration of glucocorticoids results in all of the following adverse effects except
Hypertension
Hyperkalaemia
Proximal myopathy
Ocular hypertension
Correct answer
Hypertension
Adverse effects of cyclosporin include all of the following except
Tremor
Hirsutism
Nephrotoxicity
Hypokalaemia
Correct answer
Tremor
Which of the following is a true statement about Corticosteroids
Inhibits lipocortin production
Inhibits leukotriene C4 and D4 synthesis
Inhibits platelet thromboxane A2 synthesis
Inhibits neutrophil production
Correct answer
Inhibits lipocortin production
Which of the following is true about latanoprost
Increases trabecular meshwork outflow
Increases uveoscleral outflow
Causes papillary dilatation
Causes iris hyperpigmentation by stimulating the multiplication of melanocytes
Correct answer
Increases trabecular meshwork outflow
Which of the following is a true statement about cocaine
Is a direct-acting sympathomimetic drug
Causes pupil dilation in normal people
Causes pupil constriction in Horner’s syndrome
Can be used to differentiate between preganglionic and postganglionic Horner’s syndrome
Correct answer
Is a direct-acting sympathomimetic drug
All of the following are side effects seen in α-adrenoreceptor blockers EXCEPT
Reduced tear production
Decreased corneal sensation
Myopic shift
Impotence
Correct answer
Reduced tear production
All of the following statements are correct about steroids in eyes EXCEPT
Removal of corneal epithelium will increase the ocular penetration of corticosteroid
Acetate preparation tends to come in suspension form
Phosphate preparation has a better corneal penetration than acetate preparation
Subconjunctival injection of corticosteroid achieves a better ocular penetration than topical instillation
Correct answer
Removal of corneal epithelium will increase the ocular penetration of corticosteroid
Schedule FF contains the list of the following
Standard for ophthalmic preparation
Drugs which can be marked under generic names only
Drugs which are habit-forming
Standard for cosmetics
Correct answer
Standard for ophthalmic preparation
Application form 19C is used for the following schedule
Schedule C & C1
Schedule C
Homeopathic drugs
Schedule X
Correct answer
Schedule C & C1
Schedule P includes
Central drug laboratory
Life period of drugs
Good manufacturing practices
Disinfectant fluids
Correct answer
Central drug laboratory
Schedule L is concerned with
Habit-forming drugs
Homeopathic drugs
Good Laboratory Practices (GLP)
List of drugs to be sold on prescription only
Correct answer
Habit-forming drugs
Habit-forming and psychotropic drugs are concerned with
Schedule FF
Schedule K
Schedule X
Schedule D
Correct answer
Schedule FF
State pharmacy council should have the following number of elected members
Six
Five
Nine
Seven
Correct answer
Six
Schedule O is related to
Standard for ophthalmic preparation
Standard for disinfectant fluids
For external use only
Standard for cosmetics
Correct answer
Standard for ophthalmic preparation
A mercantile agent who negotiates the purchase or sale of goods on behalf of other parties
Commission agents
Factor
Auctioneer
Broker
Correct answer
Commission agents
ABC analysis means
Average better control
Annual better control
Always better control
Arbitrarily better control
Correct answer
Average better control
A test is used to judge the mental capacity of an applicant
Personality tests
Proficiency tests
Aptitude tests
Intelligence tests
Correct answer
Personality tests
Mercantile agent is also known as
Agent middleman
Functional middleman
Both Agent middleman and Functional middleman
None of the above
Correct answer
Agent middleman
A merchant who operates entirely by buying and selling in large lots and doesn’t engage in manufacturing or retailing
Pure wholesaler
Manufacturer wholesaler
Retailer wholesaler
None of the above
Correct answer
Pure wholesaler
Reorder level is equal to
Maximum usage × Maximum lead time
Normal usage × Normal lead time
Minimum usage × Minimum lead time
Average usage × Average lead time
Correct answer
Maximum usage × Maximum lead time
Annual usage is equal to
Annual requirement - per unit cost
Annual requirement x per unit cost
Annual requirement/per unit cost
Annual requirement + per unit cost
Correct answer
Annual requirement - per unit cost
Warfarin behaves as a competitive antagonist of
Vitamin B
Vitamin C
Vitamin K
Vitamin D
Correct answer
Vitamin B
The risk of digitalis toxicity is increased by concomitant administration of
Triamterene
Captopril
Lidocaine
Hydrochlorothiazide
Correct answer
Triamterene
The xenobiotic that does not cause nephrotoxicity is
Streptozotocin
Cisplatin
Isoniazid
Gentamycin
Correct answer
Streptozotocin
Choose the drug that often causes tachycardia when given in regular doses
Isosorbide dinitrate
Verapamil
Propranolol
Guanethidine
Correct answer
Isosorbide dinitrate
Cyclophosphamide is
Anti-HIV drug
Analgesic drug
Anticancer drug
Antiepileptic drug
Correct answer
Anti-HIV drug
80 questions in the full paper