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ISRO Pharmacist Previous Year Question paper 2021

80 questions · 120 minutes · with answers · free

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Test (80 questions)

Saccharin is sweeter than sucrose by

((a))
50 times
((b))
100 times
((c))
500 times
((d))
1000 times

Show Answer

Answer: ((a))

50 times

How many millilitres of U-100 insulin should be used to obtain 40 units of insulin ?

((a))
40 ml
((b))
4 ml
((c))
0.4 ml
((d))
400 ml

Show Answer

Answer: ((a))

40 ml

In coffee seed, caffeine is present as a salt of

((a))
Chlorogenic acid
((b))
Lysergic acid
((c))
Miconic acid
((d))
Uric acid

Show Answer

Answer: ((a))

Chlorogenic acid

Prostaglandin analogues in ulcer therapy causes

((a))
Diarrhoea
((b))
Abortion
((c))
Uterine bleeding
((d))
All of the above

Show Answer

Answer: ((a))

Diarrhoea

Oral hypoglycemic agent which is a Thiazolidinedione derivative is

((a))
Repaglinide
((b))
Glipizide
((c))
Pioglitazone
((d))
Glimepiride

Show Answer

Answer: ((a))

Repaglinide

BCG vaccine is

((a))
Live attenuated viral vaccine
((b))
Live attenuated bacterial vaccine
((c))
Killed bacterial vaccine
((d))
Inactivated viral vaccine

Show Answer

Answer: ((a))

Live attenuated viral vaccine

The Central Drugs Research Institute is situated at

((a))
Kolkata
((b))
Kasauli
((c))
Izzat Nagar
((d))
Lucknow

Show Answer

Answer: ((a))

Kolkata

A receipt given by a seller to a buyer who has returned goods, which can be offset against future purchases

((a))
Credit note
((b))
Invoice
((c))
Debit note
((d))
Bill

Show Answer

Answer: ((a))

Credit note

Which of the following is not a macrolide antibiotic?

((a))
Erythromycin
((b))
Spiramycin
((c))
Azithromycin
((d))
Vancomycin

Show Answer

Answer: ((a))

Erythromycin

Morphine is present in

((a))
Atropa belladonna
((b))
Papaver somniferum
((c))
Ricinus communis
((d))
Solanum nigrum

Show Answer

Answer: ((a))

Atropa belladonna

Autoclaving of ampoules in a dye bath is for

((a))
Clarity testing
((b))
Pyrogen testing
((c))
Leak testing
((d))
Sterility testing

Show Answer

Answer: ((a))

Clarity testing

Anticancer drugs kill cancer cells by

((a))
Zero order kinetics
((b))
Pseudo first order kinetics
((c))
First order kinetics
((d))
Second order kinetics

Show Answer

Answer: ((a))

Zero order kinetics

Dopamine is degraded by

((a))
MAO-A
((b))
MAO-B
((c))
Both (a ) and (b)
((d))
None of the above

Show Answer

Answer: ((a))

MAO-A

Tyndallization is the process of

((a))
Sterilization by heating under pressure for 3 days
((b))
Sterilization by heating without pressure for 3 days
((c))
Sterilization by heating under pressure for 1 day
((d))
None of the above

Show Answer

Answer: ((a))

Sterilization by heating under pressure for 3 days

Which of the following may cause cycloplegia when used topically in the eye?

((a))
Cortisone
((b))
Physostigmine
((c))
Pilocarpine
((d))
Atropine

Show Answer

Answer: ((a))

Cortisone

Captopril exerts action by inhibiting conversion of

((a))
Angiotensin I to II
((b))
Angiotensin II to I
((c))
Angiotensinogen to Angiotensin
((d))
Angiotensin to Angiotensinogen

Show Answer

Answer: ((a))

Angiotensin I to II

The largest peak in a mass spectrum is called as

((a))
Parent peak
((b))
Daughter peak
((c))
Metastable peak
((d))
Base peak

Show Answer

Answer: ((a))

Parent peak

Keller Kiliani test is the identification test for

((a))
Digitalis
((b))
Senna
((c))
Metformin
((d))
Rifampicin

Show Answer

Answer: ((a))

Digitalis

The storage form of Iron in the human body is

((a))
Ferritin
((b))
Ferrous fumarate
((c))
Heme
((d))
Globulin

Show Answer

Answer: ((a))

Ferritin

Micromeritics refers to the study of

((a))
Microscopes
((b))
Microorganisms
((c))
Metric system of measurement
((d))
Small particles

Show Answer

Answer: ((a))

Microscopes

How many half lives is required to disintegrate 90% of a drug?

((a))
3.3
((b))
4.4
((c))
1.1
((d))
2.2

Show Answer

Answer: ((a))

3.3

A patient with Glucose 6 phosphate dehydrogenase deficiency if treated with Dapsone will develop

((a))
Hemolytic anaemia
((b))
Pernicious anaemia
((c))
Diarrhoea
((d))
None of the above

Show Answer

Answer: ((a))

Hemolytic anaemia

Aztreonam is a

((a))
Monobactum
((b))
Carbapenem
((c))
Betalactamase inhibitor
((d))
None of the above

Show Answer

Answer: ((a))

Monobactum

DOTS refers to

((a))
Divided Option Treatment System
((b))
Drug resistance Optimizing Treatment System
((c))
Directly Observed Treatment Short course
((d))
None of the above

Show Answer

Answer: ((a))

Divided Option Treatment System

Sublingually used organic nitrate is

((a))
Nitroglycerine
((b))
Isosorbide dinitrate
((c))
Isosorbide mononitrate
((d))
Both (a ) and (b)

Show Answer

Answer: ((a))

Nitroglycerine

Thromboxane is mainly synthesized by

((a))
Lungs
((b))
Spleen
((c))
Platelets
((d))
Endothelium

Show Answer

Answer: ((a))

Lungs

The Wurster process can be used to

((a))
Coat tablets
((b))
Determine the disintegration time
((c))
Gas sterilize parenteral solutions
((d))
Automatic filling of capsules

Show Answer

Answer: ((a))

Coat tablets

Emulsions containing more than two phases are called as

((a))
Mixed emulsion
((b))
Heterogenous emulsion
((c))
Homogenized emulsion
((d))
Multiple emulsion

Show Answer

Answer: ((a))

Mixed emulsion

The hypotensive effect of Clonidine is due to action on

((a))
Alpha adrenergic receptor
((b))
Beta adrenergic receptor
((c))
H1 receptor
((d))
H2 receptor

Show Answer

Answer: ((a))

Alpha adrenergic receptor

Antidiabetic agent of choice in diabetic ketoacidosis is

((a))
Protamine Zinc Insulin
((b))
Isophane Insulin
((c))
Crystalline Insulin
((d))
Tolbutamide

Show Answer

Answer: ((a))

Protamine Zinc Insulin

Black pepper consists of the dried unripe fruits of

((a))
Piper betle
((b))
Piper cubeba
((c))
Piper longum
((d))
Piper nigrum

Show Answer

Answer: ((a))

Piper betle

The reddish brown colour of calamine is due to

((a))
Zinc chloride
((b))
Ferric chloride
((c))
Ferric oxide
((d))
Potassium permanganate

Show Answer

Answer: ((a))

Zinc chloride

Disposable syringes are made of

((a))
Polypropylene
((b))
Glass
((c))
Polytetrachlorothylene
((d))
None of the above

Show Answer

Answer: ((a))

Polypropylene

Which of the following is a physical sunscreen?

((a))
TiO2
((b))
Para aminobenzoic acid
((c))
Methyl salicylate
((d))
Silicone oil

Show Answer

Answer: ((a))

TiO2

Seal coating is applied

((a))
To build up the tablet size
((b))
To prevent moisture penetration into the tablet core
((c))
To round the edges
((d))
None of the above

Show Answer

Answer: ((a))

To build up the tablet size

Which vitamin contain steroidal structure?

((a))
Vitamin E
((b))
Vitamin A
((c))
Vitamin D
((d))
Vitamin C

Show Answer

Answer: ((a))

Vitamin E

The endothelium-dependent relaxing factor of blood

((a))
Acetylcholine
((b))
Nor adrenaline
((c))
Nitric oxide
((d))
None of the above

Show Answer

Answer: ((a))

Acetylcholine

5HT3 antagonist used as anti-emetic agent

((a))
Ondansetron
((b))
Domperidone
((c))
Cisapride
((d))
Both (a) and (b)

Show Answer

Answer: ((a))

Ondansetron

All the following causes hyperglycemia except

((a))
Streptozotocin
((b))
Diazoxide
((c))
Glucagon
((d))
Miglitol

Show Answer

Answer: ((a))

Streptozotocin

The breakdown of glucose to pyruvic acid is called

((a))
Glycolysis
((b))
Glucogenesis
((c))
Glycogenolysis
((d))
TCA cycle

Show Answer

Answer: ((a))

Glycolysis

Standard for Cosmetics is included in

((a))
Schedule P
((b))
Schedule T
((c))
Schedule S
((d))
Schedule F

Show Answer

Answer: ((a))

Schedule P

Poorly manufactured tablets may have small pinholes on the surface. This is called

((a))
Mottling
((b))
Picking
((c))
Leaching
((d))
Cracking

Show Answer

Answer: ((a))

Mottling

The term bioavailability refers to the

((a))
Relationship between the physical and chemical properties of a drug and its systemic absorption
((b))
Movement of the drug into body tissues over time
((c))
Dissolution of a drug in the gastrointestinal tract
((d))
Measurement of the rate and amount of therapeutically active drug that reaches systemic circulation

Show Answer

Answer: ((a))

Relationship between the physical and chemical properties of a drug and its systemic absorption

Selective inhibition of serotonin uptake is by

((a))
Desipramine
((b))
Fluoxetine
((c))
Maprotoline
((d))
Lobeline

Show Answer

Answer: ((a))

Desipramine

Largest organ in the body is

((a))
Liver
((b))
Skin
((c))
Bone
((d))
Lungs

Show Answer

Answer: ((a))

Liver

Which one is the unit of wave number?

((a))
Kaiser
((b))
Hertz
((c))
ms^-1
((d))
cps

Show Answer

Answer: ((a))

Kaiser

Capacity limited processes can be described by

((a))
Linear kinetics
((b))
Nonlinear kinetics
((c))
Michaelis - Menten kinetics
((d))
Mixed kinetics

Show Answer

Answer: ((a))

Linear kinetics

The cytotoxic drug with maximum emetic activity is

((a))
Cisplatin
((b))
Chlorambucil
((c))
Methotrexate
((d))
Busulphan

Show Answer

Answer: ((a))

Cisplatin

Liver microsomal enzymes are stimulated by

((a))
Cimetidine
((b))
Phenobarbitone
((c))
Procaine
((d))
Adrenaline

Show Answer

Answer: ((a))

Cimetidine

Which one of the following is an example of nonionic emulsifying agent?

((a))
Yellow paraffin wax
((b))
Bee's wax
((c))
Liquid paraffin
((d))
Spans

Show Answer

Answer: ((a))

Yellow paraffin wax

Rotoweigh is used to measure

((a))
Rotation speed of capsules
((b))
Weight of capsules
((c))
Sorting speed of capsules
((d))
None of the above

Show Answer

Answer: ((a))

Rotation speed of capsules

Solid Fat Index (SFI) is determined by

((a))
Potentiometry
((b))
Amperometric titration
((c))
Voltametry
((d))
Dilatometry

Show Answer

Answer: ((a))

Potentiometry

Ergotoxine contains

((a))
Ergocryptine
((b))
Ergocristine
((c))
Ergocornin
((d))
All of the above

Show Answer

Answer: ((a))

Ergocryptine

The particles which are deeply bonded, settle rapidly, easily redispersible are known as

((a))
Coagules
((b))
Defloccules
((c))
Floccules
((d))
Sediments

Show Answer

Answer: ((a))

Coagules

Nux vomica seeds contain

((a))
Unicellular lignified covering trichomes
((b))
Unicellular conical covering trichomes
((c))
Unicellular biseriate head
((d))
Multicellular unbranched trichomes

Show Answer

Answer: ((a))

Unicellular lignified covering trichomes

The active metabolite of Diazepam

((a))
Nitrazepam
((b))
Nor Diazepam
((c))
Des methyl fluorazepam
((d))
None of the above

Show Answer

Answer: ((a))

Nitrazepam

NSAIDS produce ulcerogenic actions because

((a))
They decrease acid secretion in stomach
((b))
They increase mucus secretion in stomach
((c))
They increase mucosal blood flow in stomach
((d))
None of the above

Show Answer

Answer: ((a))

They decrease acid secretion in stomach

End product of Purine catabolism in man

((a))
Allantoin
((b))
Inosine
((c))
Uric acid
((d))
Xanthine

Show Answer

Answer: ((a))

Allantoin

Asafoetida is obtained from

((a))
Afghanistan
((b))
Spain
((c))
Burma
((d))
Malaysia

Show Answer

Answer: ((a))

Afghanistan

Liquid paraffin is of

((a))
Animal origin
((b))
Mineral origin
((c))
Synthetic origin
((d))
Semisynthetic origin

Show Answer

Answer: ((a))

Animal origin

The term MDT (Multi Drug Therapy) is related to

((a))
Leprosy
((b))
Tuberculosis
((c))
Amoebiasis
((d))
Giardiasis

Show Answer

Answer: ((a))

Leprosy

Dihydropyridine ring containing Calcium channel blocker is

((a))
Verapamil
((b))
Diltiazem
((c))
Nifedipine
((d))
Losartan

Show Answer

Answer: ((a))

Verapamil

To prevent INH induced neurotoxicity, ________ is given along with it.

((a))
Pyridoxine
((b))
Niacin
((c))
Cyanocobalamine
((d))
Riboflavin

Show Answer

Answer: ((a))

Pyridoxine

Endotoxin is produced by the following bacteria except

((a))
Salmonella typhi
((b))
Bordetella pertussis
((c))
Yersinia pestis
((d))
Clostridium tetani

Show Answer

Answer: ((a))

Salmonella typhi

The drug Amikacin is derived from

((a))
Kanamycin
((b))
Sisomicin
((c))
Gentamicin
((d))
Neomycin

Show Answer

Answer: ((a))

Kanamycin

The term Amplum denotes

((a))
Tablespoonful
((b))
Teaspoonful
((c))
Dessertspoonfu
((d))
Wineglassful

Show Answer

Answer: ((a))

Tablespoonful

Bile is produced by

((a))
Gallbladder
((b))
Liver
((c))
Pancreas
((d))
Intestine

Show Answer

Answer: ((a))

Gallbladder

Morphine does not cause

((a))
Constriction of pupil
((b))
CNS depression
((c))
Respiratory depression
((d))
Diarrhoea

Show Answer

Answer: ((a))

Constriction of pupil

Barrier creams are used to protect the skin from

((a))
Sunlight injury
((b))
Microorganisms
((c))
Viral infections
((d))
Industrial chemicals and UV rays

Show Answer

Answer: ((a))

Sunlight injury

Epinephrine is added to local anaesthetics to

((a))
Cause haemostasis
((b))
Prolong the action of the drug
((c))
Stimulate healing of wound
((d))
Decrease side effects

Show Answer

Answer: ((a))

Cause haemostasis

The phenomenon of repeated administration of a drug resulting in cell receptor blockage is known as

((a))
Tachyphylaxis
((b))
Idiosynchro
((c))
Tolerance
((d))
Synergism

Show Answer

Answer: ((a))

Tachyphylaxis

BAL is used against which metal poisoning?

((a))
Copper
((b))
Cyanide
((c))
Mercury
((d))
Iron

Show Answer

Answer: ((a))

Copper

An oral hypoglycemic agent which is a Dipeptidyl peptidase-4 inhibitor

((a))
Pioglitazone
((b))
Sitagliptin
((c))
Liraglutide
((d))
Empagliflozin

Show Answer

Answer: ((a))

Pioglitazone

A low volume of distribution of a drug indicates

((a))
Short biological life
((b))
Does not accumulate in various organs
((c))
Not bioavailable
((d))
None of the above

Show Answer

Answer: ((a))

Short biological life

The mineral deficient in milk

((a))
Phosphorous
((b))
Sodium
((c))
Potassium
((d))
Iron

Show Answer

Answer: ((a))

Phosphorous

Which of the following monoclonal antibody is fully human in origin?

((a))
Daclizumab
((b))
Infliximab
((c))
Adalimumab
((d))
Edrecolomab

Show Answer

Answer: ((a))

Daclizumab

Optic neuritis is a side effect of

((a))
Sulphasalazine
((b))
Rifampicin
((c))
Ethambutol
((d))
Pyrazinamide

Show Answer

Answer: ((a))

Sulphasalazine

Which among the following is contra indicated in patients with eGFR less than 15mg/ml/1.75m 2 ?

((a))
Insulin
((b))
Linagliptin
((c))
Metformin
((d))
None of the above

Show Answer

Answer: ((a))

Insulin

Precursor of Thyroxine, epinephrine and nor epinephrine is

((a))
Phenyl alanine
((b))
Valine
((c))
Threonine
((d))
Tyrosine

Show Answer

Answer: ((a))

Phenyl alanine

The hardness range of tablets is usually

((a))
1-2 kg
((b))
0.5-1kg
((c))
3-7 kg
((d))
None of the above

Show Answer

Answer: ((a))

1-2 kg

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