Official Paper

ISRO Pharmacist Previous Year Question paper 2017

80 questions · 120 minutes · with answers · free

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Test (80 questions)

1

The sweetening agent commonly used in the chewable tablet formula is:

  1. ((a))

    Sucrose

  2. ((b))

    Cyclamate Sodium

  3. ((c))

    Saccharin Sodium

  4. ((d))

    Mannitol

Show Answer
Answer: ((a))

Sucrose

2

Subcoating is given to the tablets:

  1. ((a))

    To increase bulk

  2. ((b))

    To avoid deterioration due to microbial attack

  3. ((c))

    To prevent the solubility in acidic media

  4. ((d))

    To avoid stickiness

Show Answer
Answer: ((a))

To increase bulk

3

The pH of a pharmaceutical buffer system can be calculated by:

  1. ((a))

    pH partition theory

  2. ((b))

    Noyes Whitney law

  3. ((c))

    Henderson Hasselbalch equation

  4. ((d))

    Michaelis Menten equation

Show Answer
Answer: ((a))

pH partition theory

4

The pharmacy council of India is constituted by:

  1. ((a))

    Central government

  2. ((b))

    State government

  3. ((c))

    Parliament

  4. ((d))

    Legislative assembly

Show Answer
Answer: ((a))

Central government

5

Poorly manufactured tablets may have small pinholes on the surface. This phenomenon is known as:

  1. ((a))

    Picking

  2. ((b))

    Mottling

  3. ((c))

    Leaching

  4. ((d))

    Cracking

Show Answer
Answer: ((a))

Picking

6

Among the following preparations, which one will be the most irritating to the eye:

  1. ((a))

    Purified water

  2. ((b))

    0.7% NaCl solution

  3. ((c))

    0.9% NaCl solution

  4. ((d))

    1% NaCl solution

Show Answer
Answer: ((a))

Purified water

7

Bubble point test is done to determine:

  1. ((a))

    The surface tension of the liquid in capillary tubes

  2. ((b))

    The viscosity of the liquid in ampoules

  3. ((c))

    The pH of a 1% solution

  4. ((d))

    The volume of a solution stored in a specific container

Show Answer
Answer: ((a))

The surface tension of the liquid in capillary tubes

8

As per GMP, the permitted limit of solid contents in water for injections is:

  1. ((a))

    100 ppm

  2. ((b))

    1.0 ppm

  3. ((c))

    0.1 ppm

  4. ((d))

    10.0 ppm

Show Answer
Answer: ((a))

100 ppm

9

License for wholesale of drugs specified in schedule C and C₁ is issued in form:

  1. ((a))

    20A

  2. ((b))

    20B

  3. ((c))

    21B

  4. ((d))

    22A

Show Answer
Answer: ((a))

20A

10

In capsules, rotofill is used for filling

  1. ((a))

    Powders

  2. ((b))

    Pellets

  3. ((c))

    Liquids

  4. ((d))

    Corrosive liquids

Show Answer
Answer: ((a))

Powders

11

Which of the following commonly available large volume dextrose solution for intravenous use is isotonic

  1. ((a))

    2.5% W/V

  2. ((b))

    5.0% W/V

  3. ((c))

    10% W/V

  4. ((d))

    20% W/V

Show Answer
Answer: ((a))

2.5% W/V

12

Which is the ideal combination for testing the solubility of an enteric coated capsule in alkaline medium?

  1. ((a))

    Sodium bicarbonate + Potassium hydroxide + Pepsin

  2. ((b))

    Sodium bicarbonate + Sodium tauroglycocholate + Papain

  3. ((c))

    Sodium bicarbonate + Pancreatin + Sodium tauroglycocholate

  4. ((d))

    Sodium bicarbonate + Bilirubin

Show Answer
Answer: ((a))

Sodium bicarbonate + Potassium hydroxide + Pepsin

13

Which one of the following is a pseudoalkaloid?

  1. ((a))

    Caffeine

  2. ((b))

    Ephedrine

  3. ((c))

    Morphine

  4. ((d))

    Codeine

Show Answer
Answer: ((a))

Caffeine

14

Which vitamin contains steroidal structure?

  1. ((a))

    Vitamin E

  2. ((b))

    Vitamin A

  3. ((c))

    Vitamin D

  4. ((d))

    None of the above

Show Answer
Answer: ((a))

Vitamin E

15

Morphine is present in

  1. ((a))

    Atropa belladonna

  2. ((b))

    Papaver somniferum

  3. ((c))

    Ricinus communis

  4. ((d))

    Solanum nigrum

Show Answer
Answer: ((a))

Atropa belladonna

16

Emetine, an alkaloid of Ipecacuanha acts as

  1. ((a))

    Antimalarial

  2. ((b))

    Antidiarrhoeal

  3. ((c))

    Antiseptic

  4. ((d))

    Amoebicide

Show Answer
Answer: ((a))

Antimalarial

17

Patient with Glucose 6 phosphate dehydrogenase deficiency is treated with Dapsone. He will suffer from

  1. ((a))

    Haemolytic anaemia

  2. ((b))

    Pernicious anaemia

  3. ((c))

    Diarrhoea

  4. ((d))

    None of the above

Show Answer
Answer: ((a))

Haemolytic anaemia

18

Which one of the following drugs is not a long acting benzodiazepine?

  1. ((a))

    Diazepam

  2. ((b))

    Clonazepam

  3. ((c))

    Flurazepam

  4. ((d))

    Midazolam

Show Answer
Answer: ((a))

Diazepam

19

Which antibiotic is used for the treatment of both tuberculosis as well as leprosy?

  1. ((a))

    Isoniazid (INH)

  2. ((b))

    Rifampicin

  3. ((c))

    Clofazimine

  4. ((d))

    Ethionamide

Show Answer
Answer: ((a))

Isoniazid (INH)

20

All the following are stimulant purgatives except

  1. ((a))

    Bisacodyl

  2. ((b))

    Castor oil

  3. ((c))

    Senna

  4. ((d))

    Liquid paraffin

Show Answer
Answer: ((a))

Bisacodyl

21

Mast cell stabilizer is

  1. ((a))

    Salbutamol

  2. ((b))

    Theophylline

  3. ((c))

    Sodium chromoglycate

  4. ((d))

    Atropine

Show Answer
Answer: ((a))

Salbutamol

22

Anticholinergic used as bronchodilator is

  1. ((a))

    Pilocarpine

  2. ((b))

    Ipratropium

  3. ((c))

    Prazosin

  4. ((d))

    Salbutamol

Show Answer
Answer: ((a))

Pilocarpine

23

Mucolytics are

  1. ((a))

    Bromohexine

  2. ((b))

    Carbocysteine

  3. ((c))

    Acetyl cysteine

  4. ((d))

    All of the above

Show Answer
Answer: ((a))

Bromohexine

24

All except ___ are antibiotics obtained from fungi.

  1. ((a))

    Penicillin

  2. ((b))

    Griseofulvin

  3. ((c))

    Cephalosporin

  4. ((d))

    Bacitracin

Show Answer
Answer: ((a))

Penicillin

25

Some bacteria develop drug resistance very rapidly except

  1. ((a))

    Staphylococci

  2. ((b))

    Coliforms

  3. ((c))

    Streptococcus pyogenes

  4. ((d))

    Tubercle bacilli

Show Answer
Answer: ((a))

Staphylococci

26

Clavulanic acid or Sulbactum is used in combination with Amoxycillin against H.influenzae because

  1. ((a))

    Clavulanic acid inhibits beta lactamase produced by H.influenzae

  2. ((b))

    Clavulanic acid is acid resistant antibiotic

  3. ((c))

    Clavulanic acid is very susceptible to H.influenzae

  4. ((d))

    None of the above

Show Answer
Answer: ((a))

Clavulanic acid inhibits beta lactamase produced by H.influenzae

27

Second line antitubercular drug is

  1. ((a))

    Streptomycin

  2. ((b))

    Capreomycin

  3. ((c))

    Ethambutol

  4. ((d))

    Rifampin

Show Answer
Answer: ((a))

Streptomycin

28

All first line TB drugs are bactericidal except

  1. ((a))

    INH

  2. ((b))

    Rifampicin

  3. ((c))

    Ethambutol

  4. ((d))

    Pyrazinamide

Show Answer
Answer: ((a))

INH

29

All the following except ___ contain imidazole ring.

  1. ((a))

    Clotrimazole

  2. ((b))

    Econazole

  3. ((c))

    Miconazole

  4. ((d))

    Ketoconazole

Show Answer
Answer: ((a))

Clotrimazole

30

In congestive cardiac failure, digitalis glycosides are used because it increases

  1. ((a))

    Heart rate

  2. ((b))

    Force of myocardial contraction

  3. ((c))

    Venous pressure

  4. ((d))

    Cardiac filling pressure

Show Answer
Answer: ((a))

Heart rate

31

In order to produce characteristic pharmacological action, a drug must always

  1. ((a))

    Reach high blood levels

  2. ((b))

    Absorb from G.I. tract readily

  3. ((c))

    Achieve adequate concentration at the site of action

  4. ((d))

    Excreted unchanged in urine

Show Answer
Answer: ((a))

Reach high blood levels

32

Heparin prevents blood coagulation by

  1. ((a))

    Inhibiting thrombin catalysed conversion of fibrinogen to fibrin

  2. ((b))

    Precipitate blood calcium thereby prevent coagulation reaction

  3. ((c))

    Inhibiting enzyme reactions

  4. ((d))

    Converting ionised calcium by chelation

Show Answer
Answer: ((a))

Inhibiting thrombin catalysed conversion of fibrinogen to fibrin

33

Which is an antimetabolite?

  1. ((a))

    Fluorouracil

  2. ((b))

    Nitrogen mustard

  3. ((c))

    Cyclophosphamide

  4. ((d))

    Chlorambucil

Show Answer
Answer: ((a))

Fluorouracil

34

Selective beta2 bronchodilator used for the treatment of status asthmaticus is

  1. ((a))

    Acetyl choline

  2. ((b))

    Isoetharine

  3. ((c))

    Terbutaline

  4. ((d))

    Dirabutero

Show Answer
Answer: ((a))

Acetyl choline

35

Belladona alkaloid (atropine) is used prior to administration of a general anaesthetic agent due to

  1. ((a))

    Inhibition of G.I.T. motility

  2. ((b))

    Prevention of miosis

  3. ((c))

    Inhibition of salivation and secretion of respiratory tract

  4. ((d))

    Causing skeletal muscle relaxation

Show Answer
Answer: ((a))

Inhibition of G.I.T. motility

36

Drug of choice in amoebic dysentery is

  1. ((a))

    Penicillin G

  2. ((b))

    Niridazole

  3. ((c))

    Metronidazole

  4. ((d))

    Tetracycline

Show Answer
Answer: ((a))

Penicillin G

37

Clinically used Uricosuric agent is

  1. ((a))

    Diazepam

  2. ((b))

    Sulfinpyrazone

  3. ((c))

    Phenylbutazone

  4. ((d))

    Phenytoin

Show Answer
Answer: ((a))

Diazepam

38

The metal used in the treatment of Rheumatoid arthritis is

  1. ((a))

    Ag

  2. ((b))

    Au

  3. ((c))

    Cu

  4. ((d))

    Sb

Show Answer
Answer: ((a))

Ag

39

The drug very effective in the treatment of acute gout is

  1. ((a))

    Aspirin

  2. ((b))

    Acetaminophen

  3. ((c))

    Phenylbutazone

  4. ((d))

    Indomethacin

Show Answer
Answer: ((a))

Aspirin

40

The Anti tubercular drug inhibiting RNA synthesis

  1. ((a))

    Streptomycin

  2. ((b))

    Ethambutol

  3. ((c))

    Chloramphenicol

  4. ((d))

    Rifampicin

Show Answer
Answer: ((a))

Streptomycin

41

The Anti tubercular drug inhibiting Protein synthesis with potential for ototoxic effect is

  1. ((a))

    Ethambutol

  2. ((b))

    Dapsone

  3. ((c))

    Streptomycin

  4. ((d))

    INH

Show Answer
Answer: ((a))

Ethambutol

42

Methotrexate is an antagonist of

  1. ((a))

    Cobalamine

  2. ((b))

    Folic acid

  3. ((c))

    Riboflavin

  4. ((d))

    Tocopherol

Show Answer
Answer: ((a))

Cobalamine

43

All are the side effects of Chloroquine except

  1. ((a))

    Blurring of vision

  2. ((b))

    Haemolytic anaemia

  3. ((c))

    Psychotic episodes

  4. ((d))

    Skin rash

Show Answer
Answer: ((a))

Blurring of vision

44

Antidote of organophosphorus poisoning is

  1. ((a))

    Nitrous oxide

  2. ((b))

    Atenolol

  3. ((c))

    Atropine

  4. ((d))

    Tubocurarine

Show Answer
Answer: ((a))

Nitrous oxide

45

Which of the following agents is a cholinesterase reactivator?

  1. ((a))

    Aspirin

  2. ((b))

    Pilocarpine

  3. ((c))

    Scopolamine

  4. ((d))

    Pralidoxime

Show Answer
Answer: ((a))

Aspirin

46

Drug of choice in the treatment of cardiogenic shock is

  1. ((a))

    Diosgenin

  2. ((b))

    Epinephrine

  3. ((c))

    Dopamine

  4. ((d))

    Ouabain

Show Answer
Answer: ((a))

Diosgenin

47

The choice of drug to treat Cerebral Malaria is

  1. ((a))

    Meparcine

  2. ((b))

    Amodiaquine

  3. ((c))

    Quinine

  4. ((d))

    Primaquine

Show Answer
Answer: ((a))

Meparcine

48

All of the following statements concerning Sulfonamides are correct except

  1. ((a))

    Inhibit dihydrofolate reductase

  2. ((b))

    Crystalluria may occur

  3. ((c))

    They are antimetabolites of PABA

  4. ((d))

    They are bacteriostatic

Show Answer
Answer: ((a))

Inhibit dihydrofolate reductase

49

Optic neuritis is a chief adverse effect of

  1. ((a))

    Sulpha drugs

  2. ((b))

    Pyrazinamide

  3. ((c))

    Rifampicin

  4. ((d))

    Ethambutol

Show Answer
Answer: ((a))

Sulpha drugs

50

Which of the following is not a Macrolide antibiotic?

  1. ((a))

    Erythromycin

  2. ((b))

    Spiramycin

  3. ((c))

    Oleandomycin

  4. ((d))

    Vancomycin

Show Answer
Answer: ((a))

Erythromycin

51

A steroidal antibiotic is

  1. ((a))

    Fucidin

  2. ((b))

    Bacitracin

  3. ((c))

    Aminophylline

  4. ((d))

    Clindamycin

Show Answer
Answer: ((a))

Fucidin

52

The preferred treatment of status epilepticus is intra venous administration of

  1. ((a))

    Ethosuximide

  2. ((b))

    Sodium valproate

  3. ((c))

    Diazepam

  4. ((d))

    Chloramphenicol

Show Answer
Answer: ((a))

Ethosuximide

53

Bromocriptine is used to treat amenorrhea because

  1. ((a))

    It stimulates the ovary

  2. ((b))

    It stimulates the GnRH release

  3. ((c))

    It suppresses the prolactin release

  4. ((d))

    It stimulates FSH release

Show Answer
Answer: ((a))

It stimulates the ovary

54

The primary mechanism of action of Local Anaesthetic is the blockade of

  1. ((a))

    Potassium channel

  2. ((b))

    Calcium channel

  3. ((c))

    Sodium channel

  4. ((d))

    All of the above

Show Answer
Answer: ((a))

Potassium channel

55

Long term use of Glucocorticoids induce

  1. ((a))

    Hypotension

  2. ((b))

    Hepatotoxicity

  3. ((c))

    Osteoporosis

  4. ((d))

    Bradycardia

Show Answer
Answer: ((a))

Hypotension

56

Clomiphene is used to treat infertility because it stimulates

  1. ((a))

    LH secretion

  2. ((b))

    Follicular development

  3. ((c))

    Ovulation

  4. ((d))

    Uterus activity

Show Answer
Answer: ((a))

LH secretion

57

Isoxuprine is used to treat

  1. ((a))

    Asthma

  2. ((b))

    Severe hypotension

  3. ((c))

    Nasal congestion

  4. ((d))

    Premature labour

Show Answer
Answer: ((a))

Asthma

58

The phenomena of invasion and destruction of tissue is known as

  1. ((a))

    Natural immunity

  2. ((b))

    Acquired immunity

  3. ((c))

    Pathogenicity

  4. ((d))

    Parasitism

Show Answer
Answer: ((a))

Natural immunity

59

Organisms that can grow on organic matter from dead plants or animals are called as

  1. ((a))

    Saprophytes

  2. ((b))

    Parasites

  3. ((c))

    Psychotrophs

  4. ((d))

    Mesophils

Show Answer
Answer: ((a))

Saprophytes

60

Glycerol may be used as a preservative in a percentage of

  1. ((a))

    15

  2. ((b))

    50

  3. ((c))

    1

  4. ((d))

    0.1

Show Answer
Answer: ((a))

15

61

The micro-organism that can enter the body only through an injury is

  1. ((a))

    Salmonella typhi

  2. ((b))

    Clostridium tetani

  3. ((c))

    Clostridium botulinum

  4. ((d))

    Streptococcus pyogenes

Show Answer
Answer: ((a))

Salmonella typhi

62

Tears contain an antibacterial enzyme known as

  1. ((a))

    Zymase

  2. ((b))

    Diastase

  3. ((c))

    Lysozyme

  4. ((d))

    Lipase

Show Answer
Answer: ((a))

Zymase

63

Protein deficiency disease is known as

  1. ((a))

    Cushing’s disease

  2. ((b))

    Fabry’s disease

  3. ((c))

    Parkinson’s disease

  4. ((d))

    Kwashiorkor and marasmus

Show Answer
Answer: ((a))

Cushing’s disease

64

Glycogen is present in all body tissue except

  1. ((a))

    Liver

  2. ((b))

    Brain

  3. ((c))

    Kidney

  4. ((d))

    Stomach

Show Answer
Answer: ((a))

Liver

65

The conversion of carotenoids to vitamin A takes place in

  1. ((a))

    Intestine

  2. ((b))

    Liver

  3. ((c))

    Kidney

  4. ((d))

    Skin

Show Answer
Answer: ((a))

Intestine

66

The precursor of bile salts, sex hormones and vitamin D is

  1. ((a))

    Diosgenin

  2. ((b))

    Cholesterol

  3. ((c))

    Campesterol

  4. ((d))

    Ergosterol

Show Answer
Answer: ((a))

Diosgenin

67

International enzyme commission classifies enzymes into

  1. ((a))

    Three classes

  2. ((b))

    Six classes

  3. ((c))

    Four classes

  4. ((d))

    Ten classes

Show Answer
Answer: ((a))

Three classes

68

Platelets contain an enzyme which has an important role in clotting of blood. This enzyme is known as

  1. ((a))

    Cholinesterase

  2. ((b))

    Transaminase

  3. ((c))

    Decarboxylase

  4. ((d))

    Thrombokinase

Show Answer
Answer: ((a))

Cholinesterase

69

Cobalt is a constituent of

  1. ((a))

    Folic acid

  2. ((b))

    Vitamin B12

  3. ((c))

    Niacin

  4. ((d))

    Biotin

Show Answer
Answer: ((a))

Folic acid

70

In the process of transcription, the flow of genetic information is from

  1. ((a))

    DNA to DNA

  2. ((b))

    DNA to Protein

  3. ((c))

    DNA to RNA

  4. ((d))

    RNA to DNA

Show Answer
Answer: ((a))

DNA to DNA

71

Milk is deficient in which mineral?

  1. ((a))

    Phosphorus

  2. ((b))

    Sodium

  3. ((c))

    Iron

  4. ((d))

    Potassium

Show Answer
Answer: ((a))

Phosphorus

72

Unopened insulin is stored at

  1. ((a))

    -1 to -5°C

  2. ((b))

    2 to 8°C

  3. ((c))

    15 to 20°C

  4. ((d))

    20 to 30°C

Show Answer
Answer: ((a))

-1 to -5°C

73

Glargine is

  1. ((a))

    Short acting insulin

  2. ((b))

    Intermediate acting insulin

  3. ((c))

    Peakless insulin

  4. ((d))

    Oral insulin

Show Answer
Answer: ((a))

Short acting insulin

74

Metformin is

  1. ((a))

    Sulfonyl urea

  2. ((b))

    DPP4 inhibitor

  3. ((c))

    Biguanide

  4. ((d))

    Alpha glucosidase inhibitor

Show Answer
Answer: ((a))

Sulfonyl urea

75

Enalapril is

  1. ((a))

    Angiotensin receptor blocker

  2. ((b))

    Ca channel blocker

  3. ((c))

    Beta blocker

  4. ((d))

    Angiotensin converting enzyme inhibitor

Show Answer
Answer: ((a))

Angiotensin receptor blocker

76

In primary vaccination DPT is given as

  1. ((a))

    Three doses at one month intervals

  2. ((b))

    Three doses at three month intervals

  3. ((c))

    Five doses at one month intervals

  4. ((d))

    Single dose

Show Answer
Answer: ((a))

Three doses at one month intervals

77

The following are NSAIDs except

  1. ((a))

    Ibuprofen

  2. ((b))

    Diclofenac sodium

  3. ((c))

    Ketotifen

  4. ((d))

    Piroxicam

Show Answer
Answer: ((a))

Ibuprofen

78

Dextromethorphan is used in cough syrups as

  1. ((a))

    Expectorant

  2. ((b))

    Mucolytic

  3. ((c))

    Bronchodilator

  4. ((d))

    Suppressant

Show Answer
Answer: ((a))

Expectorant

79

The following are Proton pump inhibitors except

  1. ((a))

    Omeprazole

  2. ((b))

    Rabiprazole

  3. ((c))

    Pantoprazole

  4. ((d))

    Albendazole

Show Answer
Answer: ((a))

Omeprazole

80

The following are true of National Pharmaceutical Pricing Authority (NPPA) except

  1. ((a))

    It is a statutory body

  2. ((b))

    It can fund studies regarding pricing of drugs

  3. ((c))

    It monitors drug shortages and takes appropriate action to rectify it

  4. ((d))

    It collects and maintains data regarding the import and export of drugs

Show Answer
Answer: ((a))

It is a statutory body

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