Which among the following is an essential mineral for both activation and action of thrombin?
- ((a))
Sodium
- ((b))
Chloride
- ((c))
Calcium
- ((d))
Magnesium
Show Answer
Calcium
Thrombin is a naturally occurring enzyme that converts fibrinogen into fibrin.

Key Points
- Blood clotting or coagulation is a mechanism that prevents the loss of blood during injury.
- During injury, the damaged platelets release the enzyme, thrombokinase that converts the inactive prothrombin into active thrombin.
- The thrombin formed converts the soluble fibrinogen into insoluble fibrin.
- Conversion of fibrinogen into fibrin is an integral step in clot formation.
- Calcium ions are essential during blood clotting.
Hence Ca2+ is essential for both activation and action of thrombin.

Additional Information
- Sodium: The human body requires a small amount of sodium to conduct nerve impulses, contract and relax muscles, and maintain the proper balance of water and minerals. It is estimated that we need about 500 mg of sodium daily for these vital functions.
- Chloride is, after sodium, the most abundant electrolyte in serum, with a key role in the regulation of body fluids, electrolyte balance, the preservation of electrical neutrality, and acid-base status and it is an essential component for the assessment of many pathological conditions.
- Magnesium is an important mineral, playing a role in over 300 enzyme reactions in the human body. Its many functions include helping with muscle and nerve function, regulating blood pressure, and supporting the immune system.



